Apr 28, 2022

All of The Bases in DNA And RNA Have Now Been Found in Meteorites


 Space rocks that fell to Earth within the last century contain the five bases that store information in DNA and RNA, scientists report April 26 in Nature Communications.

These “nucleobases” — adenine, guanine, cytosine, thymine and uracil — combine with sugars and phosphates to make up the genetic code of all life on Earth. Whether these basic ingredients for life first came from space or instead formed in a warm soup of earthly chemistry is still not known. But the discovery adds to evidence that suggests life’s precursors originally came from space, the researchers say.

Scientists have detected bits of adenine, guanine and other organic compounds in meteorites since the 1960s. Researchers have also seen hints of uracil, but cytosine and thymine remained elusive, until now.

“We’ve completed the set of all the bases found in DNA and RNA and life on Earth, and they’re present in meteorites,” says astrochemist Daniel Glavin of NASA’s Goddard Space Flight Center in Greenbelt, Md.

A few years ago, geochemist Yasuhiro Oba of Hokkaido University in Sapporo, Japan, and colleagues came up with a technique to gently extract and separate different chemical compounds in liquified meteorite dust and then analyze them.

“Our detection method has orders of magnitude higher sensitivity than that applied in previous studies,” Oba says. Three years ago, the researchers used this same technique to discover ribose, a sugar needed for life, in three meteorites.

In the new study, Oba and colleagues combined forces with astrochemists at NASA to analyze one of those three meteorite samples and three additional ones, looking for another type of crucial ingredient for life: nucleobases.

The researchers think their milder extraction technique, which uses cold water instead of the usual acid, keeps the compounds intact. “We’re finding this extraction approach is very amenable for these fragile nucleobases,” Glavin says. “It’s more like a cold brew, rather than making hot tea.”

With this technique, Glavin, Oba and their colleagues measured the abundances of the bases and other compounds related to life in four samples from meteorites that fell decades ago in Australia, Kentucky and British Columbia. In all four, the team detected and measured adenine, guanine, cytosine, uracil, thymine, several compounds related to those bases and a few amino acids.

Using the same technique, the team also measured chemical abundances within soil collected from the Australia site and then compared the measured meteorite values with that of the soil. For some detected compounds, the meteorite values were greater than the surrounding soil, which suggests that the compounds came to Earth in these rocks.

But for other detected compounds, including cytosine and uracil, the soil abundances are as much as 20 times as high as in the meteorites. That could point to earthly contamination, says cosmochemist Michael Callahan of Boise State University in Idaho.

“I think [the researchers] positively identified these compounds,” Callahan says. But “they didn’t present enough compelling data to convince me that they’re truly extraterrestrial.” Callahan previously worked at NASA and collaborated with Glavin and others to measure organic materials in meteorites.

But Glavin and his colleagues point to a few specific detected chemicals to support the hypothesis of an interplanetary origin. In the new analysis, the researchers measured more than a dozen other life-related compounds, including isomers of the nucleobases, Glavin says. Isomers have the same chemical formulas as their associated bases, but their ingredients are organized differently. The team found some of those isomers in the meteorites but not in the soil. “If there had been contamination from the soil, we should have seen those isomers in the soil as well. And we didn’t,” he says.


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